Depression has a significant impact on adolescent development and well being. Adolescent depression can adversely affect school and work performance, impair peer and family relationships, and exacerbate the severity of other health conditions such as asthma and obesity.124, 125, 126 Depressive episodes often persist, recur, or continue into adulthood.127 Youth who have had a Major Depressive Episode (MDE) in the past year are at greater risk for suicide and are more likely than other youth to initiate alcohol and other drug use, experience concurrent substance use disorders, and smoke daily.128, 129, 130
Indicator Health4: Percentage of youth ages 12–17 who experienced a Major Depressive Episode (MDE) in the past year by age and gender, 2004–2009

NOTE: Major Depressive Episode (MDE) is defined as a period of at least 2 weeks when a person experienced a depressed mood or loss of interest or pleasure in daily activities plus at least four additional symptoms of depression (such as problems with sleep, eating, energy, concentration, and feelings of self-worth) as described in the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).
SOURCE: Substance Abuse and Mental Health Services Administration, National Survey on Drug Use and Health.
HEALTH4.A HTML Table, HEALTH4.B HTML Table, HEALTH4.C HTML Table
124 Substance Abuse and Mental Health Services Administration, Office of Applied Studies. (2008). The NSDUH report: Major depressive episode among youths aged 12 to 17 in the United States: 2004 to 2006. Rockville, MD: Author. Retrieved from http://oas.samhsa.gov/2k8/youthDepress/youthDepress.cfm.
125 Van Lieshout, R.J., and MacQueen, G. (2008). Psychological factors in asthma. Allergy, Asthma and Clinical Immunology, 4 (1), 12–28.
126 Goodman, E., and Whitaker, R.C. (2007). A prospective study of the role of depression in the development and persistence of adolescent obesity. Pediatrics, 110 (3), 497–504.
127 Weissman, M.M., Wolk, S., Goldstein, R.B., Moreau, D., Adams, P., Greenwald, S., .. Wickramaratne, P. (1999). Depressed adolescents grown up. Journal of the American Medical Association, 282, 1701–1713.
128 Shaffer, D., Gould, M.S., Fisher, P., Trautman, P., Moreau, D., Kleinman, M., and Flory, M. (1996). Psychiatric diagnosis in child and adolescent suicide. Archives of General Psychiatry, 53, 339–348. Retrieved from http://archpsyc.ama-assn.org/cgi/content/abstract/53/4/339.
129 Substance Abuse and Mental Health Services Administration, Office of Applied Studies. (2007). The NSDUH report: Depression and the initiation of alcohol and other drug use among youths aged 12 to 17. Rockville, MD: Author. Retrieved from http://oas.samhsa.gov/2k7/newUsers/depression.cfm.
130 Substance Abuse and Mental Health Services Administration. (2008). Results From the 2007 National Survey on Drug Use and Health: National Findings (Office of Applied Studies, NSDUH Series H-32, DHHS Publication No. SMA 08-4343). Rockville, MD: Author.